Regulatory RNA

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Regulatory RNAs points to non-protein coding (mostly small) RNA molecules which can influence several biological processes as transcription and translation, effecting the final expression level of the target gene.

  1. miRNA - micro RNAs are endogenous post-transcriptional regulatory RNAs that bind to complementary sequences in the three prime untranslated regions (3' UTRs) of target messenger RNA transcripts (mRNAs), usually resulting in gene silencing.
  2. siRNA - a class of double-stranded RNA molecules with various role, but most acknowledged is their role in the RNA interference (RNAi) pathway, where it interferes with the expression of a specific gene.