Limma

Originally submitted by Wvandelm - wouter.vandelm@vib.be.

Name: Limma
Link: Bioconductor site
Platform: R package
Field: tools

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Purpose

Limma is a package for the analysis of gene expression microarray data, especially the use of linear models for analysing designed experiments and the assessment of differential expression. Limma provides the ability to analyze comparisons between many RNA targets simultaneously. It has features that make the analyses stable even for experiments with small number of arrays - this is achieved by borrowing information across genes. It is specially designed for analysing complex experiments with a variety of experimental conditions and predictors. The linear model and differential expression functions are applicable to data from any microarray platform, including single-channel or two-color microarray platforms. The methods are also applicable to expression data from non-microarray platforms, such as quantitative PCR, provided that a suitable matrix of expression values can be provided.

Users within VIB

Name	Email Address
Joke Allemeersch	joke.allemeersch@vib.be
Wout Van Delm	wouter.vandelm@vib.be

Tool talk

4 star rating by VIB-MAF

[Wout Van Delm] This is the default tool that we use @ VIB-MAF for running a differential expression analysis.